A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer

The doxorubicin (DOX) prodrug N -[4-doxorubicin- N -carbonyl (oxymethyl) phenyl] O -β-glucuronyl carbamate (DOX-GA3) was synthesised for specific activation by human β-glucuronidase, which is released in necrotic areas of tumour lesions. This novel prodrug was completely activated to the parent drug...

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Bibliografske podrobnosti
Main Authors: Houba, P H J, Boven, E, Meulen-Muileman, I H van der, Leenders, R G G, Scheeren, J W, Pinedo, H M, Haisma, H J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2001
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363760/
https://ncbi.nlm.nih.gov/pubmed/11207053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1640
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