The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.

The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was c...

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Main Authors: Houba, P. H., Boven, E., Erkelens, C. A., Leenders, R. G., Scheeren, J. W., Pinedo, H. M., Haisma, H. J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group|1 1998
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063245/
https://ncbi.nlm.nih.gov/pubmed/9862570
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