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Bystander killing of tumour cells by antibody-targeted enzymatic activation of a glucuronide prodrug
RHI-βG-PEG, formed by linking poly(ethylene glycol)-modified β-glucuronidase to Mab RH1, was employed to examine bystander killing of antigen-negative N1S1 rat hepatoma cells by activation of a glucuronide prodrug (BHAMG) of p-hydroxyaniline mustard (pHAM) at antigen-positive AS-30D rat hepatoma cel...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
1999
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2362709/ https://ncbi.nlm.nih.gov/pubmed/10188879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690221 |
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