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Development of a novel bi-specific monoclonal antibody approach for tumour targeting
To overcome the disadvantages of bi-specific antibody methodologies in vivo, a novel antibody approach has been designed to improve tumour targeting and effector to target ratio. The technique involves biotinylated anti-CD3 Fab fragments and streptavidinylated anti-tumour monoclonal antibodies (mAbs...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
1999
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2362912/ https://ncbi.nlm.nih.gov/pubmed/10507767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690712 |
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