Bystander killing of tumour cells by antibody-targeted enzymatic activation of a glucuronide prodrug

RHI-βG-PEG, formed by linking poly(ethylene glycol)-modified β-glucuronidase to Mab RH1, was employed to examine bystander killing of antigen-negative N1S1 rat hepatoma cells by activation of a glucuronide prodrug (BHAMG) of p-hydroxyaniline mustard (pHAM) at antigen-positive AS-30D rat hepatoma cel...

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Hlavní autoři: Cheng, T L, Wei, S L, Chen, B M, Chern, J W, Wu, M F, Liu, P W, Roffler, S R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1999
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362709/
https://ncbi.nlm.nih.gov/pubmed/10188879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690221
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