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p53 missense but not truncation mutations are associated with low levels of p21(CIP1/WAF1) mRNA expression in primary human sarcomas
Many growth-suppressing signals converge to control the levels of the CDK inhibitor p21(CIP1/WAF1). Some human cancers exhibit low levels of expression of p21(CIP1/WAF1)and mutations in p53 have been implicated in this down-regulation. To evaluate whether the presence of p53 mutations was related to...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2363685/ https://ncbi.nlm.nih.gov/pubmed/11401317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1844 |
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