p53 missense but not truncation mutations are associated with low levels of p21(CIP1/WAF1) mRNA expression in primary human sarcomas

Many growth-suppressing signals converge to control the levels of the CDK inhibitor p21(CIP1/WAF1). Some human cancers exhibit low levels of expression of p21(CIP1/WAF1)and mutations in p53 have been implicated in this down-regulation. To evaluate whether the presence of p53 mutations was related to...

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Detalhes bibliográficos
Main Authors: Mousses, S, Gokgoz, N, Wunder, J S, Ozcelik, H, Bull, S, Bell, R S, Andrulis, I L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2001
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363685/
https://ncbi.nlm.nih.gov/pubmed/11401317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1844
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