Nitric oxide synthase inhibition results in synergistic anti-tumour activity with melphalan and tumour necrosis factor alpha-based isolated limb perfusions

Nitric oxide (NO) is an important molecule in regulating tumour blood flow and stimulating tumour angiogenesis. Inhibition of NO synthase by L-NAME might induce an anti-tumour effect by limiting nutrients and oxygen to reach tumour tissue or affecting vascular growth. The anti-tumour effect of L-NAM...

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Главные авторы: de Wilt, J H W, Manusama, E R, van Etten, B, van Tiel, S T, Jorna, A S, Seynhaeve, A L B, ten Hagen, T L M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2000
Предметы:
Regular Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363576/
https://ncbi.nlm.nih.gov/pubmed/11027431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1447
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