Isolated limb perfusion with actinomycin D and TNF-alpha results in improved tumour response in soft-tissue sarcoma-bearing rats but is accompanied by severe local toxicity

Previously we demonstrated that addition of Tumour Necrosis Factor-α to melphalan or doxorubicin in a so-called isolated limb perfusion results in synergistic antitumour responses of sarcomas in both animal models and patients. Yet, 20 to 30% of the treated tumours do not respond. Therefore agents t...

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Autori principali: Seynhaeve, A L B, de Wilt, J H W, van Tiel, S T, Eggermont, A M M, ten Hagen, T L M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2002
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364186/
https://ncbi.nlm.nih.gov/pubmed/11953868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600169
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