Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines

Gemcitabine and paclitaxel are active agents in the treatment of non-small-cell lung cancer (NSCLC). To optimize treatment drug combinations, simultaneously and 4 and 24 h intervals, were studied using DNA flow cytometry and multiple drug effect analysis in the NSCLC cell lines H460, H322 and Lewis...

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Detalhes bibliográficos
Main Authors: Kroep, J R, Giaccone, G, Tolis, C, Voorn, D A, Loves, W J P, Groeningen, C J van, Pinedo, H M, Peters, G J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363564/
https://ncbi.nlm.nih.gov/pubmed/10993656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1399
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