Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines

2′,2′-Difluorodeoxycytidine (gemcitabine, dFdC) and cis-diammine-dichloroplatinum (cisplatin, CDDP) are active agents against ovarian cancer and non-small-cell lung cancer (NSCLC). CDDP acts by formation of platinum (Pt)–DNA adducts; dFdC by dFdCTP incorporation into DNA, subsequently leading to inh...

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Detalhes bibliográficos
Main Authors: Moorsel, C J A van, Pinedo, H M, Veerman, G, Bergman, A M, Kuiper, C M, Vermorken, J B, van der Vijgh, W J F, Peters, G J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363050/
https://ncbi.nlm.nih.gov/pubmed/10362105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690452
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