Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line

Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The β-actin promote...

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Autors principals: Tokunaga, T, Tsuchida, T, Kijima, H, Okamoto, K, Oshika, Y, Sawa, N, Ohnishi, Y, Yamazaki, H, Miura, S, Ueyama, Y, Nakamura, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2000
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363525/
https://ncbi.nlm.nih.gov/pubmed/10952790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1363
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