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Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line
Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The β-actin promote...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2363525/ https://ncbi.nlm.nih.gov/pubmed/10952790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1363 |
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