Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours

Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-...

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Detalles Bibliográficos
Autores principales: Wang, Z-J, Churchman, M, Campbell, I G, Xu, W-H, Yan, Z-Y, McCluggage, W G, Foulkes, W D, Tomlinson, I P M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363028/
https://ncbi.nlm.nih.gov/pubmed/10389980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690323
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