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Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li–Fraumeni syndrome

We have analysed Li–Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family membe...

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Bibliografiske detaljer
Main Authors: Burt, E C, McGown, G, Thorncroft, M, James, L A, Birch, J M, Varley, J M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363026/
https://ncbi.nlm.nih.gov/pubmed/10389970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690313
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