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Gene-specific repair of Pt/DNA lesions and induction of apoptosis by the oral platinum drug JM216 in three human ovarian carcinoma cell lines sensitive and resistant to cisplatin

JM216, an oral platinum drug entering into phase III clinical trial, exhibited comparable cytotoxicity to cisplatin in three human ovarian carcinoma cell lines: the sensitive (CH1), acquired resistant (CH1cisR) and intrinsically resistant (SKOV-3). Platinum accumulation and binding to DNA were simil...

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Detaylı Bibliyografya
Asıl Yazarlar: O’Neill, C F, Koberle, B, Masters, J R W, Kelland, L R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 1999
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362973/
https://ncbi.nlm.nih.gov/pubmed/10604725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6694381
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