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Gene-specific repair of Pt/DNA lesions and induction of apoptosis by the oral platinum drug JM216 in three human ovarian carcinoma cell lines sensitive and resistant to cisplatin

JM216, an oral platinum drug entering into phase III clinical trial, exhibited comparable cytotoxicity to cisplatin in three human ovarian carcinoma cell lines: the sensitive (CH1), acquired resistant (CH1cisR) and intrinsically resistant (SKOV-3). Platinum accumulation and binding to DNA were simil...

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Bibliografiske detaljer
Main Authors: O’Neill, C F, Koberle, B, Masters, J R W, Kelland, L R
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362973/
https://ncbi.nlm.nih.gov/pubmed/10604725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6694381
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