Gene-specific repair of Pt/DNA lesions and induction of apoptosis by the oral platinum drug JM216 in three human ovarian carcinoma cell lines sensitive and resistant to cisplatin

JM216, an oral platinum drug entering into phase III clinical trial, exhibited comparable cytotoxicity to cisplatin in three human ovarian carcinoma cell lines: the sensitive (CH1), acquired resistant (CH1cisR) and intrinsically resistant (SKOV-3). Platinum accumulation and binding to DNA were simil...

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Detalhes bibliográficos
Main Authors: O’Neill, C F, Koberle, B, Masters, J R W, Kelland, L R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362973/
https://ncbi.nlm.nih.gov/pubmed/10604725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6694381
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