Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients

Dihydropyrimidine dehydrogenase (DPD) is responsible for the breakdown of the widely used antineoplastic agent 5-fluorouracil (5FU), thereby limiting the efficacy of the therapy. To identify patients suffering from a complete or partial DPD deficiency, the activity of DPD is usually determined in pe...

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Detaylı Bibliyografya
Asıl Yazarlar: Kuilenburg, A B P Van, Lenthe, H van, Blom, M J, Mul, E P J, Gennip, A H Van
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 1999
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362418/
https://ncbi.nlm.nih.gov/pubmed/10027339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690097
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