Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. We report lymphocytic DPD data concerning a group of 53 patients (23 men, 30 women, mean age 58, range 36–73), treated by 5-FU-based chemotherapy in different French institutions and wh...

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Autores principales: Milano, G, Etienne, M C, Pierrefite, V, Barberi-Heyob, M, Deporte-Fety, R, Renée, N
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362417/
https://ncbi.nlm.nih.gov/pubmed/10027340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690098
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