Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR

We report the generation of a chimeric monoclonal antibody (ch806) with specificity for an epitope on the epidermal growth factor receptor (EGFR) that is different from that targeted by all other anti-EGFR therapies. Ch806 antibody is reactive to both de2-7 and overexpressed wild-type (wt) EGFR but...

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Hlavní autoři: Panousis, C, Rayzman, V M, Johns, T G, Renner, C, Liu, Z, Cartwright, G, Lee, F-T, Wang, D, Gan, H, Cao, D, Kypridis, A, Smyth, F E, Brechbiel, M W, Burgess, A W, Old, L J, Scott, A M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2005
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361945/
https://ncbi.nlm.nih.gov/pubmed/15770208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602470
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