Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant–dependent lung carcinomas

Activating EGFR mutations occur in human non–small cell lung cancer (NSCLC), with 5% of human lung squamous cell carcinomas having EGFRvIII mutations and approximately 10%–30% of lung adenocarcinomas having EGFR kinase domain mutations. An EGFR-targeting monoclonal antibody, mAb806, recognizes a con...

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Main Authors: Li, Danan, Ji, Hongbin, Zaghlul, Sara, McNamara, Kate, Liang, Mei-Chih, Shimamura, Takeshi, Kubo, Shigeto, Takahashi, Masaya, Chirieac, Lucian R., Padera, Robert F., Scott, Andrew M., Jungbluth, Achim A., Cavenee, Webster K., Old, Lloyd J., Demetri, George D., Wong, Kwok-Kin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1770949/
https://ncbi.nlm.nih.gov/pubmed/17256054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30446
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