A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors

An array of cell-surface antigens expressed by human cancers have been identified as targets for antibody-based therapies. The great majority of these antibodies do not have specificity for cancer but recognize antigens expressed on a range of normal cell types (differentiation antigens). Over the p...

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Bibliographic Details
Main Authors: Scott, Andrew M., Lee, Fook-Thean, Tebbutt, Niall, Herbertson, Rebecca, Gill, Sanjeev S., Liu, Zhanqi, Skrinos, Effie, Murone, Carmel, Saunder, Timothy H., Chappell, Bridget, Papenfuss, Anthony T., Poon, Aurora M. T., Hopkins, Wendie, Smyth, Fiona E., MacGregor, Duncan, Cher, Lawrence M., Jungbluth, Achim A., Ritter, Gerd, Brechbiel, Martin W., Murphy, Roger, Burgess, Antony W., Hoffman, Eric W., Johns, Terrance G., Old, Lloyd J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805701/
https://ncbi.nlm.nih.gov/pubmed/17360479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611693104
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