A pilot study of monoclonal antibody cG250 and low dose subcutaneous IL-2 in patients with advanced renal cell carcinoma

The chimeric monoclonal antibody cG250 recognizes the CAIX/MN antigen. cG250 induces antibody-dependent cellular cytotoxicity (ADCC) responses in vitro that can be enhanced by IL-2. We studied the effects of adding daily low-dose subcutaneous IL-2 to cG250 for treatment of clear cell renal cell carc...

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Main Authors: Davis, Ian D., Liu, Zhanqi, Saunders, Wayne, Lee, Fook-Thean, Spirkoska, Violeta, Hopkins, Wendie, Smyth, Fiona E., Chong, Geoffrey, Papenfuss, Anthony T., Chappell, Bridget, Poon, Aurora, Saunder, Timothy H., Hoffman, Eric W., Old, Lloyd J., Scott, Andrew M.
Format: Artigo
Sprog:Inglês
Udgivet: Academy of Cancer Immunology 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935743/
https://ncbi.nlm.nih.gov/pubmed/17705350
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