Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors

Organ-specific differences in epidermal growth factor receptor (EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Thos...

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Bibliografische gegevens
Hoofdauteurs: Weber, F, Fukino, K, Sawada, T, Williams, N, Sweet, K, Brena, R M, Plass, C, Caldes, T, Mutter, G L, Villalona-Calero, M A, Eng, C
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2005
Onderwerpen:
Genetics and Genomics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361765/
https://ncbi.nlm.nih.gov/pubmed/15841079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602557
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