Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells

Glioblastoma is characterised by invasive growth and a high degree of radioresistance. Survivin, a regulator of chromosome segregation, is highly expressed and known to induce radioresistance in human gliomas. In this study, we examined the effect of survivin suppression on radiosensitivity in malig...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Saito, T, Hama, S, Izumi, H, Yamasaki, F, Kajiwara, Y, Matsuura, S, Morishima, K, Hidaka, T, Shrestha, P, Sugiyama, K, Kurisu, K
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2008
Pynciau:
Translational Therapeutics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361434/
https://ncbi.nlm.nih.gov/pubmed/18195712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604160
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