Centrosome amplification drives chromosomal instability in breast tumor development

Earlier studies of invasive breast tumors have shown that 60–80% are aneuploid and ≈80% exhibit amplified centrosomes. In this study, we investigated the relationship of centrosome amplification with aneuploidy, chromosomal instability, p53 mutation, and loss of differentiation in human breast tumor...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lingle, Wilma L., Barrett, Susan L., Negron, Vivian C., D'Assoro, Antonino B., Boeneman, Kelly, Liu, Wanguo, Whitehead, Clark M., Reynolds, Carol, Salisbury, Jeffrey L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122305/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11830638/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.032479999
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