Centrosome amplification drives chromosomal instability in breast tumor development

Earlier studies of invasive breast tumors have shown that 60–80% are aneuploid and ≈80% exhibit amplified centrosomes. In this study, we investigated the relationship of centrosome amplification with aneuploidy, chromosomal instability, p53 mutation, and loss of differentiation in human breast tumor...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lingle, Wilma L., Barrett, Susan L., Negron, Vivian C., D'Assoro, Antonino B., Boeneman, Kelly, Liu, Wanguo, Whitehead, Clark M., Reynolds, Carol, Salisbury, Jeffrey L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 2002
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC122305/
https://ncbi.nlm.nih.gov/pubmed/11830638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032479999
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