Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma

Overexpression of the transcriptional activator β-catenin, mostly owing to loss-of-function mutations of the adenomatous polyposis coli (APC) tumour suppressor gene, is crucial for the initiation and progression of human colorectal carcinogenesis. Securin is a regulator of chromosome separation and...

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Detalles Bibliográficos
Main Authors: Hlubek, F, Pfeiffer, S, Budczies, J, Spaderna, S, Jung, A, Kirchner, T, Brabletz, T
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2006
Assuntos:
Molecular Diagnostics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361298/
https://ncbi.nlm.nih.gov/pubmed/16705313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603155
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