β-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer

Most colorectal cancers have loss of function mutations in the adenomatosis polyposis coli (APC) tumor suppressor gene. This leads to accumulation of β-catenin, which together with the DNA binding protein TCF-4 functions as a transcriptional activator. Recently defined target genes are c-myc and cyc...

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Bibliographic Details
Main Authors: Brabletz, Thomas, Jung, Andreas, Dag, Serpil, Hlubek, Falk, Kirchner, Thomas
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 1999
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Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867011/
https://ncbi.nlm.nih.gov/pubmed/10514384
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