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TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt

The majority of leukaemic cells are resistant to apoptosis induced by tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). Here, we show that sublethal concentrations of arsenic trioxide (ATO) specifically enhanced TRAIL-induced apoptosis in leukaemic but not in other tumour cell lines....

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Szegezdi, E, Cahill, S, Meyer, M, O'Dwyer, M, Samali, A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361137/
https://ncbi.nlm.nih.gov/pubmed/16434995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602954
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