Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers

Deleterious mutations in the BRCA1 gene predispose women to an increased risk of breast and ovarian cancer. Many functional studies have suggested that BRCA1 has a role in DNA damage repair and failure in the DNA damage response pathway often leads to the accumulation of chromosomal aberrations. Her...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kote-Jarai, Z, Salmon, A, Mengitsu, T, Copeland, M, Ardern-Jones, A, Locke, I, Shanley, S, Summersgill, B, Lu, Y-j, Shipley, J, Eeles, R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2006
Pynciau:
Genetics and Genomics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361110/
https://ncbi.nlm.nih.gov/pubmed/16404418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602912
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