A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers

Variation in the penetrance estimates for BRCA1 and BRCA2 mutation carriers suggests that other genetic polymorphisms may modify the cancer risk in carriers. The RAD51 gene, which participates in homologous recombination double-strand breaks (DSB) repair in the same pathway as the BRCA1 and BRCA2 ge...

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Detalhes bibliográficos
Main Authors: Kadouri, L, Kote-Jarai, Z, Hubert, A, Durocher, F, Abeliovich, D, Glaser, B, Hamburger, T, Eeles, R A, Peretz, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409456/
https://ncbi.nlm.nih.gov/pubmed/15138485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601837
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