Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP

Data are presented on pharmacodynamic (PD) method validation and preliminary clinical qualification of three PD biomarker assays. M65 Elisa, which quantitates different forms of circulating cytokeratin 18 (CK18) as putative surrogate markers of both apoptotic and nonapoptotic tumour cell death, was...

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Main Authors: Cummings, J, Ranson, M, LaCasse, E, Ganganagari, J R, St-Jean, M, Jayson, G, Durkin, J, Dive, C
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2006
Ábhair:
Translational Therapeutics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360484/
https://ncbi.nlm.nih.gov/pubmed/16804528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603220
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