Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer

Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and senescence. We propose that these steps are necessary but not sufficient to produce invasive breast cancer because intraductal tumour growth is al...

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Main Authors: Gatenby, R A, Smallbone, K, Maini, P K, Rose, F, Averill, J, Nagle, R B, Worrall, L, Gillies, R J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360372/
https://ncbi.nlm.nih.gov/pubmed/17687336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603922
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