Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells

Overexpression of Aurora-A kinase has been correlated with cancer susceptibility and poor prognosis in several human cancers. In this study, we evaluated the effect of inhibition of Aurora-A kinase on cell cycle progression and tumour cell survival after exposure to ionising radiation (IR). Combined...

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Autores principales: Tao, Y, Zhang, P, Frascogna, V, Lecluse, Y, Auperin, A, Bourhis, J, Deutsch, E
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2007
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360282/
https://ncbi.nlm.nih.gov/pubmed/18026198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604083
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