Multiple mechanisms underlie defective recognition of melanoma cells cultured in three-dimensional architectures by antigen-specific cytotoxic T lymphocytes

Cancer cells’ growth in three-dimensional (3D) architectures promotes resistance to drugs, cytokines, or irradiation. We investigated effects of 3D culture as compared to monolayers (2D) on melanoma cells’ recognition by tumour-associated antigen (TAA)-specific HLA-A(*)0201-restricted cytotoxic T-ly...

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Detalhes bibliográficos
Main Authors: Feder-Mengus, C, Ghosh, S, Weber, W P, Wyler, S, Zajac, P, Terracciano, L, Oertli, D, Heberer, M, Martin, I, Spagnoli, G C, Reschner, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360115/
https://ncbi.nlm.nih.gov/pubmed/17342088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603664
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