Adaptive dosing and platinum–DNA adduct formation in children receiving high-dose carboplatin for the treatment of solid tumours

A pharmacokinetic–pharmacodynamic study was carried out to investigate the feasibility and potential importance of therapeutic monitoring following high-dose carboplatin treatment in children. High-dose carboplatin was administered over 3 or 5 days, with the initial dose based on renal function, to...

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Hlavní autoři: Veal, G J, Errington, J, Tilby, M J, Pearson, A D J, Foot, A B M, McDowell, H, Ellershaw, C, Pizer, B, Nowell, G M, Pearson, D G, Boddy, A V
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360071/
https://ncbi.nlm.nih.gov/pubmed/17299395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603607
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