Pharmacokinetics and metabolism of 13-cis-retinoic acid (isotretinoin) in children with high-risk neuroblastoma – a study of the United Kingdom Children's Cancer Study Group

The administration of 13-cis-retinoic acid (13-cisRA), following myeloablative therapy improves 3-year event-free survival rates in children with high-risk neuroblastoma. This study aimed to determine the degree of inter-patient pharmacokinetic variation and extent of metabolism in children treated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Veal, G J, Cole, M, Errington, J, Pearson, A D J, Foot, A B M, Whyman, G, Boddy, A V
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Clinical Study
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360017/
https://ncbi.nlm.nih.gov/pubmed/17224928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603554
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