Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction

The cytotoxic effects of anticancer immune cells are mediated by perforin/granzyme-B, Fas ligand and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), and therefore depend on intact apoptotic responses in target tumour cells. As killing by all three of these mechanisms is blocked by...

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Bibliografiske detaljer
Main Authors: Lickliter, J D, Cox, J, McCarron, J, Martinez, N R, Schmidt, C W, Lin, H, Nieda, M, Nicol, A J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360057/
https://ncbi.nlm.nih.gov/pubmed/17311012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603599
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