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Imaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugates
[Image: see text] Overexpression of anti-apoptotic proteins such as Bcl-2 is a cellular mechanism to evade apoptosis; consequently, Bcl-2 inhibitors are being developed as anticancer agents. In this work, we have synthesized a fluorescent version of ABT-199 in an effort to visualize a drug surrogate...
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| Publicado no: | Bioconjug Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4240345/ https://ncbi.nlm.nih.gov/pubmed/25333750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500433k |
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