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Imaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugates
[Image: see text] Overexpression of anti-apoptotic proteins such as Bcl-2 is a cellular mechanism to evade apoptosis; consequently, Bcl-2 inhibitors are being developed as anticancer agents. In this work, we have synthesized a fluorescent version of ABT-199 in an effort to visualize a drug surrogate...
Enregistré dans:
| Publié dans: | Bioconjug Chem |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2014
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4240345/ https://ncbi.nlm.nih.gov/pubmed/25333750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500433k |
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