Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression

Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms affecting Aβ generation in sporadic AD. Deficiency in Aβ clearance is certainly a possibility, but increased expression of proteins like A...

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Bibliografski detalji
Glavni autori: Hébert, Sébastien S., Horré, Katrien, Nicolaï, Laura, Papadopoulou, Aikaterini S., Mandemakers, Wim, Silahtaroglu, Asli N., Kauppinen, Sakari, Delacourte, André, De Strooper, Bart
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359789/
https://ncbi.nlm.nih.gov/pubmed/18434550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710263105
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