Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells

The deoxycytidine analogue 2′,2′-difluoro-2′-deoxycytidine (dFdC, gemcitabine) is a potent radiosensitiser, but has limited efficacy in combination with radiotherapy in patients with pancreatic cancer due to acute toxicity. We investigated whether cyclopentenyl cytosine (CPEC), targetting the ‘de no...

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Bibliografiske detaljer
Main Authors: van Bree, C, Rodermond, H M, Leen, R, Medema, J P, van Kuilenburg, A B P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359636/
https://ncbi.nlm.nih.gov/pubmed/18349845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604287
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