Cell death induction by the acute promyelocytic leukemia-specific PML/RARα fusion protein

PML/RARα is the abnormal protein product generated by the acute promyelocytic leukemia-specific t(15;17). Expression of PML/RARα in hematopoietic precursor cell lines induces block of differentiation and promotes survival. We report here that PML/RARα has a potent growth inhibitory effect on all non...

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Main Authors: Ferrucci, Pier Francesco, Grignani, Francesco, Pearson, Mark, Fagioli, Marta, Nicoletti, Ildo, Pelicci, Pier Giuseppe
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences of the USA 1997
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC23524/
https://ncbi.nlm.nih.gov/pubmed/9380732
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