Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B an...

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Detalhes bibliográficos
Main Authors: Kakeya, Hiroshi, Miyazaki, Yoshitsugu, Senda, Hisato, Kobayashi, Tsutomu, Seki, Masafumi, Izumikawa, Koichi, Yamamoto, Yoshihiro, Yanagihara, Kazunori, Tashiro, Takayoshi, Kohno, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346668/
https://ncbi.nlm.nih.gov/pubmed/18299408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01370-07
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