Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis

SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphoter...

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Autors principals: Kakeya, Hiroshi, Miyazaki, Yoshitsugu, Senda, Hisato, Kobayashi, Tsutomu, Seki, Masafumi, Izumikawa, Koichi, Yanagihara, Kazunori, Yamamoto, Yoshihiro, Tashiro, Takayoshi, Kohno, Shigeru
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346659/
https://ncbi.nlm.nih.gov/pubmed/18299412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01369-07
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