Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

Activating mutations in tyrosine kinase (TK) genes (eg, FLT3 and KIT) are found in more than 30% of patients with de novo acute myeloid leukemia (AML); many groups have speculated that mutations in other TK genes may be present in the remaining 70%. We performed high-throughput resequencing of the k...

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Hauptverfasser: Tomasson, Michael H., Xiang, Zhifu, Walgren, Richard, Zhao, Yu, Kasai, Yumi, Miner, Tracie, Ries, Rhonda E., Lubman, Olga, Fremont, Daved H., McLellan, Michael D., Payton, Jacqueline E., Westervelt, Peter, DiPersio, John F., Link, Daniel C., Walter, Matthew J., Graubert, Timothy A., Watson, Mark, Baty, Jack, Heath, Sharon, Shannon, William D., Nagarajan, Rakesh, Bloomfield, Clara D., Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343607/
https://ncbi.nlm.nih.gov/pubmed/18270328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-113027
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