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Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

The scrapie prion protein (PrP(Sc)) is the major, and possibly the only, component of the infectious prion; it is generated from the cellular isoform (PrP(C)) by a conformational change. N-terminal truncation of PrP(Sc) by limited proteolysis produces a protein of ≈142 residues designated PrP 27–30,...

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Guardat en:
Publicat a:Proc Natl Acad Sci U S A
Autors principals: James, Thomas L., Liu, He, Ulyanov, Nikolai B., Farr-Jones, Shauna, Zhang, Hong, Donne, David G., Kaneko, Kiyotoshi, Groth, Darlene, Mehlhorn, Ingrid, Prusiner, Stanley B., Cohen, Fred E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1997
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23313/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9294167/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.19.10086
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