Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

Studies on the transmission of human (Hu) prions to transgenic (Tg) mice suggested that another molecule provisionally designated protein X participates in the formation of nascent scrapie isoform of prion protein (PrP(Sc)). We report the identification of the site at which protein X binds to the ce...

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Autores principales: Kaneko, Kiyotoshi, Zulianello, Laurence, Scott, Michael, Cooper, Carol M., Wallace, Andrew C., James, Thomas L., Cohen, Fred E., Prusiner, Stanley B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC23307/
https://ncbi.nlm.nih.gov/pubmed/9294164
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