Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

Studies on the transmission of human (Hu) prions to transgenic (Tg) mice suggested that another molecule provisionally designated protein X participates in the formation of nascent scrapie isoform of prion protein (PrP(Sc)). We report the identification of the site at which protein X binds to the ce...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kaneko, Kiyotoshi, Zulianello, Laurence, Scott, Michael, Cooper, Carol M., Wallace, Andrew C., James, Thomas L., Cohen, Fred E., Prusiner, Stanley B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9294164/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.19.10069
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